Trade names Periactin MedlinePlus a682541 Molar mass 287.398 g/mol | AHFS/Drugs.com Monograph CAS ID 129-03-3 | |
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Pregnancycategory AU: AUS: B (No risk in non-human studies) |
Weight gain cyproheptadine
Cyproheptadine (/ˌsaɪproʊˈhɛptədiːn/), sold under the brand name Periactin or Peritol, is a first-generation antihistamine with additional anticholinergic, antiserotonergic, and local anesthetic properties.
Contents
- Weight gain cyproheptadine
- Cyproheptadine
- Medical uses
- Adverse effects
- Overdose
- Pharmacology
- Pharmacokinetics
- Veterinary use
- References
Cyproheptadine
Medical uses
Adverse effects
Adverse effects include
Research has shown a suppression of growth hormone with doses of 8–12 mg per day taken for 5 days.
Overdose
Gastric decontamination measures such as activated charcoal are sometimes recommended in cases of overdose. The symptoms are usually indicative of CNS depression (or conversely CNS stimulation in some) and excess anticholinergic side effects. The LD50 in mice is 123 mg/kg and 295 mg/kg in rats.
Pharmacology
Cyproheptadine is known to be an antagonist (or inverse agonist depending on the site in question) of the receptors listed in the table below.
Acronyms used:
RC - Cloned rat receptor.
MN - Mouse NG108-15 receptor.
Pharmacokinetics
Cyproheptadine is well-absorbed following oral ingestion, with peak plasma levels occurring after 1–3 hours. Its half-life when taken orally is approximately 8 hours.
Veterinary use
Cyproheptadine is used in cats as an appetite stimulant and as an adjunct in the treatment of asthma. Possible adverse effects include excitement and aggressive behavior. The elimination half-life of cyproheptadine in cats is 12 hours.
Cyproheptadine has been used successfully in treatment of pituitary pars intermedia dysfunction in horses.