Species Human Entrez 9133 | Human Mouse Ensembl ENSG00000157456 | |
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Aliases CCNB2, HsT17299, Cyclin B2 External IDs MGI: 88311 HomoloGene: 74359 GeneCards: CCNB2 | ||
G2/mitotic-specific cyclin-B2 is a protein that in humans is encoded by the CCNB2 gene.
Contents
Function
Cyclin B2 is a member of the cyclin family, specifically the B-type cyclins. The B-type cyclins, B1 and B2, associate with p34cdc2 and are essential components of the cell cycle regulatory machinery. B1 and B2 differ in their subcellular localization. Cyclin B1 co-localizes with microtubules, whereas cyclin B2 is primarily associated with the Golgi region. Cyclin B2 also binds to transforming growth factor beta RII and thus cyclin B2/cdc2 may play a key role in transforming growth factor beta-mediated cell cycle control.
Interactions
Cyclin B2 has been shown to interact with TGF beta receptor 2.
References
Cyclin B2 Wikipedia(Text) CC BY-SA