Culpeper, Colepeper, or Culpepper is a surname. Notable people with the surname include:
The Barons Culpeper, including:
Sir Thomas Culpeper, 3rd Baronet (1588–1651), English politician
The Barons Colepeper, including:
John Colepeper, 1st Baron Colepeper (d. 1660), English politician, Chancellor of the Exchequer 1643–1646
Thomas Colepeper, 2nd Baron Colepeper (1635–1689), English colonial governor of Virginia
Alan Culpepper (b. 1972), American distance runner, married to Shayne Culpepper
Allen Ross Culpepper (1944–1969), American army captain cited for "extraordinary heroism" in the Vietnam War
Bobby Culpepper (1941–2015), American lawyer and politician
Brad Culpepper (b. 1969), American football player
Daunte Culpepper (b. 1977), American football player
John Culpeper (1366–1414), knight in the court of Henry V
John Culpepper (1761–1841), U.S. Representative from North Carolina
Martyn Culpepper (fl. 1573–1599), English academic administrator at the University of Oxford
Marvin T. Culpepper (1908–1970), member of the Louisiana House of Representatives
Nicholas Culpeper (1616–1654), English botanist, herbalist, physician, and astrologer
Robert C. Culpepper (1873–1950), American politician and judge
Shayne Culpepper (b. 1973), American middle distance athlete
Thomas Culpeper (1514–1541), courtier of Henry VIII
William A. Culpepper (1916–2015), state court judge in Louisiana
William T. Culpepper, III (b. 1947), North Carolina General Assemblyman
