Cubilin

Updated on Dec 19, 2024

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Species Human Entrez 8029		Human Mouse Ensembl ENSG00000107611

Aliases CUBN, IFCR, MGA1, gp280, cubilin External IDs MGI: 1931256 HomoloGene: 37434 GeneCards: CUBN

Cubilin is a protein that in humans is encoded by the CUBN gene.

Function

Cubilin (CUBN) acts as a receptor for intrinsic factor-vitamin B₁₂ complexes. The role of receptor is supported by the presence of 27 CUB domains. Cubulin is located within the epithelium of intestine and kidney. Mutations in CUBN may play a role in autosomal recessive megaloblastic anemia. A complex of amnionless and cubilin forms the cubam receptor.

References

Cubilin Wikipedia

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