Samiksha Jaiswal (Editor)

Amnionless

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Covid-19
Species  Human
Entrez  81693
Human  Mouse
Ensembl  ENSG00000166126
Amnionless
Aliases  AMN, PRO1028, amnionless, Amnionless, amnion associated transmembrane protein
External IDs  MGI: 1934943 HomoloGene: 12804 GeneCards: AMN

Amnionless is a protein that in humans is encoded by the AMN gene.

Function

A complex of amnionless and cubilin forms the cubam receptor.

The protein encoded by this gene is a type I transmembrane protein. It is thought to modulate bone morphogenetic protein (BMP) receptor function by serving as an accessory or coreceptor, and thus facilitates or hinders BMP binding. It is known that the mouse AMN gene is expressed in the extraembryonic visceral endoderm layer during gastrulation, but it is found to be mutated in amnionless mouse. The encoded protein has sequence similarity to short gastrulation (Sog) and procollagen IIA proteins in Drosophila.

References

Amnionless Wikipedia


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