Crain is a surname. Notable people with the surname include:
Clayton Crain, comic book artist
Dunham Jones Crain (1831–1908), New York politician and diplomat
Floyd H. Crain (born 1929), American politician
Jeanne Crain (1925–2003), actress
Jesse Crain (born 1981), baseball player
Joel Burditt Crain (1813–1887), Sergeant Major to Sam Houston
John L. Crain, president of Southeastern Louisiana University
Kurt Crain (1964–2012), American football player
Thomas C. T. Crain (1860–1942), New York County D.A.
William C. Crain (1798–1865), New York politician
