Entrez 727 | Ensembl ENSG00000106804 | |
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Aliases C5, C5D, C5a, C5b, CPAMD4, ECLZB, complement component 5 External IDs OMIM: 120900 MGI: 96031 HomoloGene: 20412 GeneCards: C5 | ||
Complement component 5 is a protein that in humans is encoded by the C5 gene.
Contents
Complement component 5 is involved in the complement system. It is cleaved into C5a and C5b:
Deficiency is thought to cause Leiner's disease.
Function
Complement component 5 is the fifth component of complement, which plays an important role in inflammatory and cell killing processes. This protein is composed of alpha and beta polypeptide chains that are linked by a disulfide bridge. An activation peptide, C5a, which is an anaphylatoxin that possesses potent spasmogenic and chemotactic activity, is derived from the alpha polypeptide via cleavage with a convertase. The C5b macromolecular cleavage product can form a complex with the C6 complement component, and this complex is the basis for formation of the membrane attack complex, which includes additional complement components.
Clinical significance
Mutations in this gene cause complement component 5 deficiency, a disease where patients show a propensity for severe recurrent infections. Defects in this gene have also been linked to a susceptibility to liver fibrosis and to rheumatoid arthritis.
Therapeutic applications
The drug eculizumab (trade name Soliris) prevents cleavage of C5 into C5a and C5b.