Colombo is an Italian surname. Notable people with the surname include:
Cristoforo Colombo, the Italian language name of Italian explorer Christopher Columbus
Emilio Colombo, Prime Minister of Italy 1970–1972 and subsequently lifetime Senator
Gherardo Colombo (born 1946), Italian magistrate
Gioacchino Colombo, Italian automobile engine designer
Giovanni Colombo (1902–1992), Cardinal and Archbishop of Milan
Giuseppe Colombo "Bepi", Italian mathematician
Joe Cesare Colombo (1930–1971), Italian industrial designer
Jürgen Colombo, German track cyclist
Luca Colombo, Italian racing cyclist
María Colombo, Argentine field hockey player
Realdo Colombo, anatomist and surgeon from the 16th century
Roberto Colombo, former Grand Prix motorcycle racer.
Umberto Colombo (1927–2006), Italian scientist
Colombo crime family of New York, its namesake Joseph Colombo
