CoA disulfide reductase

In enzymology, a CoA-disulfide reductase (EC 1.8.1.14) is an enzyme that catalyzes the chemical reaction

The 3 substrates of this enzyme are CoA, NAD⁺, and NADP⁺, whereas its 4 products are CoA-disulfide, NADH, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on a sulfur group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is CoA:NAD(P)+ oxidoreductase. Other names in common use include CoA-disulfide reductase (NADH2), NADH2:CoA-disulfide oxidoreductase, CoA:NAD+ oxidoreductase, CoADR, and coenzyme A disulfide reductase.