ATC code C03BA03 (WHO) PubChem CID 2804 UNII 17S83WON0I Molar mass 345.846 g/mol | CAS Number 636-54-4 ChemSpider 2702 CAS ID 636-54-4 | |
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AHFS/Drugs.com International Drug Names | ||
Clopamide (trade name Brinaldix) is a piperidine diuretic.
Contents
Medical vocabulary what does clopamide mean
Mechanism of action
Clopamide is categorised as a thiazide-like diuretic and works in similar way as the thiazide diuretics do. It acts in the kidneys, at the proximal convoluted tubule (PCT) of the nephron where it inhibits the sodium-chloride symporter. Clopamide selectively binds at the chloride binding site of the sodium-chloride symporter in the PCT cells on the luminal (interior) side and thus interferes with the reabsorption of sodium chloride, causing an equiosmolar excretion of water along with sodium chloride.
References
Clopamide Wikipedia(Text) CC BY-SA