Myrie was born on 25 August 1964 in Bolton, Lancashire, England, to Jamaican immigrant parents. His mother was a seamstress who later worked for Mary Quant, whilst his father was a factory worker making car batteries. His parents later divorced, and his father returned on retirement to Jamaica. Myrie was educated at Hayward Grammar School in his home-town of Bolton, and at the University of Sussex, graduating in 1985 with a law degree.
Myrie joined the BBC on the corporation's graduate journalism programme. His first assignment was as a reporter for Radio Bristol in 1988, returning to the BBC after a year with Independent Radio News. He then reported for Points West, and latterly BBC Television and Radio News.
In 1996, he became a BBC foreign correspondent, and has since reported from more than 80 countries. He initially became the BBC's Tokyo correspondent, and was then the Los Angeles correspondent from 1997 to 1999. He was appointed a BBC Asia Correspondent in 2002 and was Paris correspondent from 2006 to 2007. His career has encompassed major stories such as the impeachment of U.S. President Bill Clinton, and wars in Kosovo, Afghanistan and Iraq.
Myrie has won several nominations for his work, most significantly for his role in the Bafta-nominated team behind coverage of the Mozambique floods. He was awarded the Bayeux-Calvados Award for war correspondents for his reporting of ethnic violence on the island of Borneo.
After latterly serving as Europe correspondent based in Brussels, he was appointed a presenter on the BBC News Channel in April 2009, replacing the retired Chris Lowe. Since joining BBC News, Myrie has presented the BBC Weekend News and weekend editions of BBC News at Ten and BBC Breakfast, both on BBC One. In June 2014, he began presenting weekday bulletins on BBC One.
In September 2010, Myrie broke the story that ETA had declared a unilateral ceasefire after he met an ETA operative in Paris, who handed over a tape of the organisation's leaders making the declaration.
He currently presents the 18:30-00:00 slot, Monday to Thursday, on the BBC News Channel. During the 2015 General Election, he was the main presenter of Election Tonight at 19:30 and 21:30.
Myrie reported extensively from Kathmandu on the earthquake that struck the city on 25 April 2015, including the rescues of two Nepali citizens who were found alive under two collapsed buildings on 30 April 2015.Myrie has occasionally presented on BBC World News, including World News Today, World News America and the 2016 US Election.
He appeared as a guest on BBC One's Have I Got News for You on 15 April 2016.
In September 2017, Myrie appeared as a panellist on Richard Osman's House of Games gameshow.
Myrie is married. He enjoys cinema and jazz music and supports Manchester City.