Cline is a surname. Notable people with the surname include:
Catherine Ann Cline (1927–2005), American historian and author
Charles E. Cline, American politician
Edward Cline (b. 1946), American screenwriter and director
Eric Cline (b. 1955), Canadian politician
Eric H. Cline (b. 1960), American archaeologist
Ernest Cline (b. 1972), American comedian and screenwriter
Isaac Cline (1861–1955), American meteorologist
Kristi Cline (b. 1980), Playboy playmate
Leticia Cline (b. 1978), American model and wrestling personality
Maggie Cline, (1857–1923), Irish American vaudeville singer
Martin Cline (b. 1934), American geneticist
Melanie Cline (b. 1975), American BMX racer
Melissa S. Cline, American biologist
Monk Cline (1858–1916), American baseball player
Nels Cline (b. 1956), American guitarist and composer
Ollie Cline (1925–2001), American football player
Patsy Cline (1932–1963), country music star (born Virginia Hensley)
Russell Cline (born c. 1965), American currency trader and conman
Sperry Cline (d. 1964), Canadian frontier policeman
Ty Cline (b. 1939), American baseball player
Victor Cline (born c. 1950), American psychoanalyst
Reginald Cline-Cole (fl. c. 2000), Sierra Leonean professor of developmental geography
