Girish Mahajan (Editor)

Clear cell renal cell carcinoma

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Clear cell renal cell carcinoma

The Clear Cell Renal Cell Carcinoma (CCRCC) is a type of Renal cell carcinoma.

Contents

Epidemiology

  • Most commonly affects male patients in their sixties and seventies.
  • Majority of CCRCC arise sporadically.
  • Only 2 – 4% of the cases presenting as part of an inherited cancer syndrome, as von Hippel-Lindau syndrome.

    • Microscopy

    Generally, the cells have a clear cytoplasm, are surrounded by a distinct cell membrane and contain round and uniform nuclei.

    Cytogenetics

  • Alterations of chromosome 3p segments occurs in 70 – 90% of CCRCCs
  • Inactivation of von Hippel-Lindau disease (VHL) gene by gene mutation and promoter hypermethylation
  • Gain of chromosome 5q
  • Loss of chromosomes 8p, 9p, and 14q

    • Molecular genetics

    Several frequently mutated genes were discovered in CCRCC: VHL, KDM6A/UTX, SETD2, KDM5C/JARID1C and MLL2.

    Histogenesis

    CCRCC is derived from the proximal convoluted tubule.

    References

    Clear cell renal cell carcinoma Wikipedia
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