Cisthene or Kisthene (Ancient Greek: Κισθήνη) was a coastal town in ancient Aeolis, opposite Lesbos Island, in western Mysia; its mines were a source of copper.
Its location is not certain, but it is generally considered to be near modern Ayvalık on the northwestern Aegean coast of Turkey. During the survey project, realized by Engin Beksaç, in 1997, it was possible for Prof. Beksaç, to identify the place of Kisthene, as Kızçiftlik, on the Plains of Gömeç, near Ayvalık (ancient Greek Kydonies-Κυδωνιές). The site is near the sea, and faces towards the Peninsula of Pryha. And by a cooperation of Kızçiftlik, it has been destroyed partially. A great many of the archaeological data, from the Early Bronze Age up to Late Byzantine Period, have identified by Prof. Beksaç on the surface. According to the information, provided by Strabon, the ruins, identified by Prof. Beksaç, are related to Kisthene(2).