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Chronic allograft nephropathy, abbreviated CAN and also known as sclerosing/chronic allograft nephropathy, is the leading cause of kidney transplant failure and happens month to years after the transplant.
Contents
Symptoms
CAN is characterized by a gradual decline in kidney function and, typically, accompanied by high blood pressure and hematuria.
Diagnosis
CAN is diagnosed by examination of tissue, e.g. a kidney biopsy.
Pathology
The histopathology is characterized by interstitial fibrosis, tubular atrophy, fibrotic intimal thickening of arteries and glomerulosclerosis.
References
Chronic allograft nephropathy Wikipedia(Text) CC BY-SA