Chordin like 1

Function

This gene encodes an antagonist of bone morphogenetic protein 4. The encoded protein may play a role in topographic retinotectal projection and in the regulation of retinal angiogenesis in response to hypoxia. Alternatively spliced transcript variants encoding different isoforms have been described.

Clinical significance

Mutations in CHRDL1 are associated to Neuhäuser Syndrome , X-linked megalocornea and central corneal thickness .