Puneet Varma (Editor)

Cholecystokinin A receptor

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Species
  
Human

Entrez
  
886

Human
  
Mouse

Ensembl
  
ENSG00000163394

Cholecystokinin A receptor

Aliases
  
CCKAR, CCK-A, CCK1-R, CCK1R, CCKRA, cholecystokinin A receptor

External IDs
  
MGI: 99478 HomoloGene: 37337 GeneCards: CCKAR

The Cholecystokinin A receptor is a human protein, also known as CCKAR or CCK1, with CCK1 now being the IUPHAR-recommended name.

Contents

Function

This gene encodes a G-protein coupled receptor that binds sulfated members of the cholecystokinin (CCK) family of peptide hormones. This receptor is a major physiologic mediator of pancreatic enzyme secretion and smooth muscle contraction of the gallbladder and stomach. In the central and peripheral nervous system this receptor regulates satiety and the release of beta-endorphin and dopamine.

The extracellular, N-terminal, domain of this protein adopts a tertiary structure consisting of a few helical turns and a disulfide-cross linked loop. It is required for interaction of the cholecystokinin A receptor with its corresponding hormonal ligand.

Agonists

  • Cholecystokinin
  • Gastrin
  • CCK-4
  • SR-146,131
  • A-71623 - modified tetrapeptide, potent and selective CCKA agonist, IC50 3.7nM, 1200x selectivity over CCKB, CAS# 130408-77-4
  • Antagonists

  • Proglumide
  • Lorglumide
  • Devazepide
  • Dexloxiglumide
  • Asperlicin
  • SR-27897
  • IQM-95333
  • JNJ-17156516
  • References

    Cholecystokinin A receptor Wikipedia