Cheyne is both a surname and a given name. Notable people with the name include:
Surname:
John Cheyne (speaker) Speaker of the House (14th century)
John Cheyne, Baron Cheyne (c1445–1499), English courtier and hostage after the Treaty of Picquigny (1475)
John Cheyne (physician) (1777–1836), British physician, surgeon and author
George Cheyne (physician) (1671–1743), physician and medical writer
Sir Reginald Cheyne, (fl.13thc.), Lord Chamberlain of Scotland
Thomas Cheney (Cheyne) (c1485–1558), Lord Warden of the Cinque Ports
Thomas Kelly Cheyne (1841–1915), English divine and Biblical critic
Sir William Cheyne, 1st Baronet (1852–1932), British surgeon and bacteriologist who pioneered the use of antiseptical surgical methods in the United Kingdom
John Cheyne (1905), British lawyer, see Bannatyne v Overtoun
Given name:
Cheyne Coates, Australian dance music and pop singer
