Chemical modification

Updated on Nov 06, 2023

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Chemical modification in chemistry

Chemical modification describes the modification, addition or removal, through chemical reaction, of any of a variety of macromolecules, including proteins and nucleic acids.

Chemically modified electrodes

Chemically modified electrodes are electrodes that have their surfaces chemically modified to change the electrode's physical, chemical, electrochemical, optical, electrical, and transport properties. These electrodes are used for advanced purposes in research and investigation.

Chemical modification in biochemistry

In biochemistry, chemical modification is the technique of chemically reacting a protein or nucleic acid with chemical reagents. Chemical modification can have several goals, such as

to identify which parts of the molecule are exposed to solvent ("foot printing");

to determine which residues are important for a particular phenotype, e.g., which residues are important for an enzymatic activity;

to introduce new groups into a macromolecule; and

to crosslink macromolecules intra- and intermolecularly.

Chemical modification of protein side chains

Iodoacetamide

Iodoacetic acid

PEGylation

BisSulfosuccinimidyl suberate

1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide

N-Ethylmaleimide

Methyl methanethiosulfonate (MMTS)

MTSL

References

Chemical modification Wikipedia

(Text) CC BY-SA

Chemical modification in chemistry

Contents

Chemically modified electrodes

Chemical modification in biochemistry

Chemical modification of protein side chains

References