Although she is from Portsmouth, her family originated from Liverpool, and she is a lifelong Liverpool fan. She spent much of her early years in Wickham, a village just north of Portsmouth.
She was also a singer and backing vocalist and was a backing vocalist for Tony Christie for a TV appearance of his hit, "Is This the Way to Amarillo". She hosted the Barnardos Young Supporters Concert from 2005–2009, and participated in Catfight in 2007, a boxing match in Hammersmith Palais.
In 2004 Jackson wrote and presented sports news for a variety of sports websites, including sportal.com, TEAMtalk, Football365 and Golf365 among other sports related websites—where she wrote and presented sports bulletins. Jackson also presented the coverage of the National Hunt Festival for the official Cheltenham website in 2006.
She joined Setanta Sports News in 2007, co-hosting Lunchtime Live alongside Murray Dron, and presented various live events, including BetFred League of Legends darts tournament. She presented the Beijing Bulletin for Al Jazeera +3 Sport's coverage of the 2008 Summer Olympics, with Rhodri Williams.
In 2005 she appeared in Clarkson: Heaven and Hell as a dancer.
After the channel ceased broadcasting in June 2009, she joined Sky Sports in August 2009, presenting on Sky Sports News. She also regularly appears with Tim Shaw on his radio show, Absolution. She hosted the 2009 FIFA World Player of the Year Awards Ceremony in Zurich alongside Pedro Pinto. She appeared as a reporter in the Keith Lemon film.
Jackson presented Sky Sports Football quiz show Take it Like a Fan with John Fendley. The show is based on going to different British football league grounds and asking quiz questions.
She also presented the second series of ITV's 71 Degrees North alongside Paddy McGuinness, and was team captain for the girls for ITV's The Big Quiz—Sports Special.
In 2013, she was a contestant in ITV's celebrity diving show Splash!, where she reached the semi-finals, despite breaking a toe.
She is married to Wales football manager Chris Coleman. She announced in June 2014 that they were expecting their first child and a son arrived 22 December.
In late 2010, early 2011, Jackson found herself at the centre of controversy. Sky Sports commentator Andy Gray and Sky Sports presenter Richard Keys were caught making off air comments about a female linesman which were considered sexist. Shortly after, footage emerged of Gray making a comment to Jackson that was also deemed sexist, and ended up costing Gray his job.