In small capillary hemodynamics, the cell-free layer is a near-wall layer of plasma absent of red blood cells since they are subject to migration to the capillary center in Poiseuille flow. Cell-free marginal layer model is a mathematical model which tries to explain Fåhræus–Lindqvist effect mathematically.
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Governing equations
Consider steady flow of blood through a capillary of radius
where:
Boundary conditions
The boundary conditions to obtain the solution for the two differential equations presented above are that the velocity gradient is zero in the tube center, no slip occurs at the tube wall and the velocity and the shear stress are continuous at the interface between the two zones. These boundary conditions can be expressed mathematically as:
Velocity profiles
Integrating governing equations with respect to r and applying the above discussed boundary conditions will result in:
Volumetric flow rate
Total volumetric flow rate is the algebraic sum of the flow rates in core and plasma region. The expression for the total volumetric flow rate can be written as:
Comparison with the viscosity which applies in the Poiseuille flow yields effective viscosity,
It can be realized when the radius of the blood vessel is very larger than the thickness of the cell-free plasma layer, the effective viscosity is equal to bulk blood viscosity