Girish Mahajan

Cefpodoxime

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AHFS/Drugs.com  Monograph
Routes of administration  Oral
MedlinePlus  a698024
ATC code  J01DD13 (WHO)
Cefpodoxime
Trade names  Generic (formerly Vantin)
Pregnancy category  AU: B1 US: B (No risk in non-human studies)

Cefpodoxime is an oral, third-generation cephalosporin antibiotic. It is active against most Gram-positive and Gram-negative organisms. Notable exceptions include Pseudomonas aeruginosa, Enterococcus, and Bacteroides fragilis. Currently, it is only marketed as generic preparations in the USA, according to the FDA Orange Book. It is commonly used to treat acute otitis media, pharyngitis, sinusitis, and gonorrhea. It also finds use as oral continuation therapy when intravenous cephalosporins (such as ceftriaxone) are no longer necessary for continued treatment.

Contents

Zoetis markets cefpodoxime proxetil under the trade name Simplicef for veterinary use. The dose range in dogs is 5–10 mg/kg body weight, administered orally, once a day.

Finecure, India markets the products under trade name Cefpo.

Cefpodoxime inhibits cell wall synthesis by inhibiting the final transpeptidation step of peptidoglycan synthesis in cell walls. It has well established pharmacokinetic profile with absorption of 50%. It is indicated in community acquired pneumonia, uncomplicated skin and skin structure infections, and uncomplicated urinary tract infections.

Spectrum of bacterial susceptibility and resistance

Cefpodoxime has been used to fight pathogenic bacteria responsible for causing gonorrhoea, tonsillitis, pneumonia, and bronchitis. Representative pathogenic genera include Streptococcus, Haemophilus, and Neisseria. The following represents MIC susceptibility data for a few medically significant microorganisms.

  • Haemophilus influenzae: ≤0.03 - 1 μg/ml
  • Neisseria gonorrhoeae: 0.004 - 0.06 μg/ml
  • Streptococcus pyogenes: ≤0.004 - 2 μg/ml
  • Brand Name

    Brand Name: Toraxim (Delta Pharma Ltd. Bangladesh), Trucef (by Renata Limited, Bangladesh).

    Marketed Also As : Orelox By SanoFi-Aventis Pharma MAPDOX-CV Cefpodoxime and Clavulanic acid combination

    MONOTAX O (Cefpodoxime)/ MONOTAX CV (Cefpodoxime and Clavulanic acid combination)- ZYDUS BIOCHEM

    References

    Cefpodoxime Wikipedia


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