Aliases CASP14 Human Mouse Ensembl ENSG00000105141 | Species Human Entrez 23581 | |
 | ||
External IDs MGI: 1335092 HomoloGene: 36304 GeneCards: CASP14 | ||
Medical vocabulary what does caspase 14 mean
Caspase 14 is an enzyme that in humans is encoded by the CASP14 gene.
Contents
- Medical vocabulary what does caspase 14 mean
- Gene music using protein sequence of casp14 caspase 14 apoptosis related cysteine peptidase
- References
The CASP14 gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This caspase has been shown to be processed and activated by caspase 8 and caspase 10 in vitro, and by anti-Fas agonist antibody or TNF-related apoptosis inducing ligand in vivo. The expression and processing of this caspase may be involved in keratinocyte terminal differentiation, which is important for the formation of the skin barrier.