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Casomorphin

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Casomorphin

Casomorphins are peptides, i.e., protein fragments, derived from the digestion of milk protein casein.

Contents

Health

Digestive enzymes can break casein down into peptides that have some biological activity in cells and in laboratory animals though conclusive causal effects on humans have not been established. Although they have not yet been proven to be formed in the human digestive system, there are associations between serum levels of β -casomorphins and the risk of sudden infant death syndrome, histamine release, stimulation of food intake, specifically high-fat foods, and lymphocytosis.


Although research has shown high rates of use of complementary and alternative therapies for children with autism, including gluten and/or casein exclusion diets, as of 2008 there was a lack of evidence that these diets had any effect.

β-Casomorphin 1-3

  • Structure: H-Tyr-Pro-Phe-OH
  • Chemical formula: C23H27N3O5
  • Molecular weight: 425.48 g/mo
  • Bovine β-casomorphin 1-4

  • Structure: H-Tyr-Pro-Phe-Pro-OH
  • Chemical formula: C28H35N4O6
  • Molecular weight: 522.61 g/mol
  • Bovine β-casomorphin 1-4, amide

  • Structure: H-Tyr-Pro-Phe-Pro-NH2
  • Chemical formula: C28H35N5O5
  • Molecular weight: 521.6 g/mol
  • Also known as morphiceptin

    Bovine β-casomorphin 5

  • Structure: H-Tyr-Pro-Phe-Pro-Gly-OH
  • Chemical formula: C30H37N5O7
  • Molecular weight: 594.66 g/mol
  • Bovine β-casomorphin 7

  • Structure: H-Tyr-Pro-Phe-Pro-Gly-Pro-Ile-OH
  • Chemical formula: C41H55N7O9
  • Molecular weight: 789.9 g/mol
  • Bovine β-casomorphin 8

  • Structure: H-Tyr-Pro-Phe-Pro-Gly-Pro-Ile-Pro-OH
  • Chemical formula: C46H62N8O10
  • Molecular weight: 887.00 g/mol
  • (Note: There is also a form of bovine β-Casomorphin 8 that has histidine instead of proline in position 8, depending on whether it is derived from A1 or A2 beta-casein.)

    References

    Casomorphin Wikipedia