EC number 3.1.1.45 IntEnz IntEnz view ExPASy NiceZyme view | CAS number 76689-22-0 BRENDA BRENDA entry KEGG KEGG entry | |
In enzymology, a carboxymethylenebutenolidase (EC 3.1.1.45) is an enzyme that catalyzes the chemical reaction
4-carboxymethylenebut-2-en-4-olide + H2OThus, the two substrates of this enzyme are 4-carboxymethylenebut-2-en-4-olide and H2O, whereas its product is 4-oxohex-2-enedioate.
This enzyme belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. The systematic name of this enzyme class is 4-carboxymethylenebut-2-en-4-olide lactonohydrolase. Other names in common use include maleylacetate enol-lactonase, dienelactone hydrolase, and carboxymethylene butenolide hydrolase. This enzyme participates in gamma-hexachlorocyclohexane degradation and 1,4-dichlorobenzene degradation.
Structural studies
As of late 2007, 10 structures have been solved for this class of enzymes, with PDB accession codes 1DIN, 1GGV, 1ZI6, 1ZI8, 1ZI9, 1ZIC, 1ZIX, 1ZIY, 1ZJ4, and 1ZJ5.