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Carboxylate transporter

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A carboxylate transporter is a membrane transport protein that transports carboxylate.

Contents

They are responsible for the reabsorption of filtered carboxylate in renal physiology, resulting in a 100% reabsorption in the proximal tubule.

In proximal tubule

In the renal proximal tubule, there are several kinds of carboxylate transporters in the apical membrane and the basolateral membrane.

Apical

  • Na-monocarboxylate cotransporter
  • 3Na-dicarboxylate cotransporter
  • 3Na-tricarboxylate cotransporter

    • Basolateral

  • H-monocarboxylate cotransporter
  • organic anion-dicarboxylate exchanger

    • References

    Carboxylate transporter Wikipedia
    (Text) CC BY-SA