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Carboxy lyases

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Carboxy-lyases, also known as decarboxylases, are carbon–carbon lyases that add or remove a carboxyl group from organic compounds. These enzymes catalyze the decarboxylation of amino acids, beta-keto acids and alpha-keto acids.

Contents

Classification and nomenclature

Carboxy-lyases are categorized under EC number 4.1.1. Usually, they are named after the substrate whose decarboxylation they catalyze, for example Pyruvate decarboxylase catalyzes the decarboxylation of Pyruvate

Examples

  • Aromatic-L-amino-acid decarboxylase
  • Glutamate decarboxylase
  • Histidine decarboxylase
  • Ornithine decarboxylase
  • Phosphoenolpyruvate carboxylase
  • Pyruvate decarboxylase
  • RuBisCO – the only carboxylase that leads to a net fixation of carbon dioxide
  • Uridine monophosphate synthetase
  • Uroporphyrinogen III decarboxylase

    • References

    Carboxy-lyases Wikipedia
    (Text) CC BY-SA