|Trade names Toxivenol|
ATC code B02BX02 (WHO)
PubChem CID 5360410
administration P/O, I/M|
CAS Number 69-81-8
Molar mass 236.23 g/mol
|AHFS/Drugs.com International Drug Names|
Carbazochrome is an antihemorrhagic, or hemostatic, agent that will cease blood flow by causing the aggregation and adhesion of platelets in the blood to form a platelet plug, ceasing blood flow from an open wound. It is hoped that this drug can be used in the future for preventing excessive blood flow during surgical operations and the treatment of hemorrhoids, but research on its effectiveness and the severity of possible side effects remains to be fairly inconclusive.
With troxerutin, it has been investigated for use in the treatment of hemorrhoids.
How to pronounce carbazochrome
Capillary and parenchymal hemorrhage (trauma, tonsillectomy, during surgery), intestinal bleeding, thrombocytopenic purpura.
Mechanism of action
Carbazochrome, the semicarbazone of adrenochrome, that interacts with α-adrenoreceptors on surface of platelets, which are coupled to Gq protein and initiate PLC IP3/DAG pathway to increase intracellular free calcium concentration with these subsequent actions:
Because of its poor solubility in water it must be first thoroughly dissolved in alcohol, melted fat (butter), or vegetable oil (to aid in absorption) and then ingested.