Supriya Ghosh

Carbamoyl phosphate

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Formula  CH2NO5P2-
Molar mass  141.02 g/mol
Carbamoyl phosphate Question 6A Answer

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Carbamoyl phosphate is an anion of biochemical significance. In land-dwelling animals, it is an intermediary metabolite in nitrogen disposal through the urea cycle and the synthesis of pyrimidines.

Contents

Carbamoyl phosphate FileCarbamoylphosphatepng Wikimedia Commons

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Production

Carbamoyl phosphate httpsuploadwikimediaorgwikipediacommonsthu

It is produced from bicarbonate, ammonia (derived from glutamine), and phosphate (from ATP). The synthesis is catalysed by the enzyme carbamoyl phosphate synthetase, as follows:

Carbamoyl phosphate Carbamoyl Phosphate Synthase I
  • HCO
    3
    + ATP → ADP + HO–C(O)–OPO2−
    3
    (carboxyl phosphate)
  • HO–C(O)–OPO2−
    3
    + NH3 + OHHPO2−
    4
    + O–C(O)NH2 + H2O
  • O–C(O)NH2 + ATP → ADP + H
    2
    NC(O)OPO2−
    3


  • Carbamoyl phosphate FileCarbamoylphosphatepng Wikimedia Commons

    References

    Carbamoyl phosphate Wikipedia


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