Symbol CLCA_N InterPro IPR013642 OPM superfamily 517 | Pfam PF08434 TCDB 1.A.17 OPM protein 4wis | |
The calcium-activated chloride channels (CaCCs), are heterogeneous groups of ligand-gated ion channels for chloride that have been identified in many epithelial and endothelial cell types as well as in smooth muscle cells. They include proteins from several structurally different families: chloride channel accessory (CLCA), bestrophin (BEST), and anoctamin (ANO or TMEM16) channels ANO1 is highly expressed in human gastrointestinal interstitial cells of Cajal, which are proteins which serve as intestinal pacemakers for peristalsis. In addition to their role as chloride channels some CLCA proteins function as adhesion molecules and may also have roles as tumour suppressors.
Contents
In humans
CaCCs that are known to occur in humans include:
Functions
Secrete chloride into lumen