Caine is a surname of several different origins. In many cases it is a variation of the surname Cain.
When the surname is of French origin, in some cases it is derived from a derogatory nickname for someone with a bad temper - from the French caigne "bitch".
Notable people with the surname include:
Hall Caine, British novelist and playwrightHugh Le Caine, Canadian physicist, composer and instrument builderMarti Caine, (1945–1995), English comedian and singerMartin Caine, American college football head coachMichael Caine, British film actorNatalie Caine (1909–2008), also known by her married name Natalie James, English oboistRachel Caine, pen name of Roxanne Longstreet Conrad, an American writer of science fiction storiesRebecca Caine, Canadian opera singerShakira Caine, Guyanan model, married to Michael CaineStanley Caine (1936–2013), English actorTrudi Le Caine (née Janowski), an arts patron, wife of Hugh Le CaineWilliam Caine, Governor-general of Hong KongWilliam Sproston Caine (1842–1903), British politician and Temperance advocate