Cagle is an American surname resulting from the Anglicization of the German surname Kegel. Notable people with the surname include:
Casey Cagle (born 1966), American politician
Chris Cagle (born 1968), American country music singer, apparent relative of football player Chris
Chris "Red" Cagle (1905-1942), American football player
Daryl Cagle (born 1956), American cartoonist
Harold Cagle (1913-1977), American Olympic athlete
Joey Allen (neé Joseph Allen Cagle, born 1964), American glam metal guitarist
Sandy Cagle (born 1957), American model
Susan Justice (neé Susan Cagle, born 1981), American pop-rock singer
Susie Cagle, American journalist/cartoonist, daughter of Daryl
Yvonne Cagle (born 1959), American astronaut