Rahul Sharma (Editor)

Caffeoyl CoA O methyltransferase

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EC number
  
2.1.1.104

IntEnz
  
IntEnz view

ExPASy
  
NiceZyme view

CAS number
  
120433-42-3

BRENDA
  
BRENDA entry

KEGG
  
KEGG entry

In enzymology, a caffeoyl-CoA O-methyltransferase (EC 2.1.1.104) is an enzyme that catalyzes the chemical reaction

S-adenosyl-L-methionine + caffeoyl-CoA S-adenosyl-L-homocysteine + feruloyl-CoA

Thus, the two substrates of this enzyme are S-adenosyl methionine and caffeoyl-CoA, whereas its two products are S-adenosylhomocysteine and feruloyl-CoA. A large number of natural products are generated via a step involving this enzyme.

This enzyme is classified to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:caffeoyl-CoA 3-O-methyltransferase. Other names in common use include caffeoyl coenzyme A methyltransferase, caffeoyl-CoA 3-O-methyltransferase, and trans-caffeoyl-CoA 3-O-methyltransferase. This enzyme participates in phenylpropanoid biosynthesis.

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1SUI and 1SUS.

References

Caffeoyl-CoA O-methyltransferase Wikipedia