Species Human Entrez 8738 | Human Mouse Ensembl ENSG00000169372 | |
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Aliases CRADD, MRT34, RAIDD, CASP2 and RIPK1 domain containing adaptor with death domain External IDs MGI: 1336168 HomoloGene: 2821 GeneCards: CRADD | ||
Death domain-containing protein CRADD is a protein that in humans is encoded by the CRADD gene.
Contents
Function
The protein encoded by this gene is a death domain (CARD/DD)-containing protein and has been shown to induce cell apoptosis. Through its CARD domain, this protein interacts with, and thus recruits, caspase 2/ICH1 to the cell death signal transduction complex that includes tumor necrosis factor receptor 1 (TNFR1A), RIPK1/RIP kinase, and numbers of other CARD domain-containing proteins.
Interactions
CRADD has been shown to interact with RIPK1 and Caspase 2.
References
CRADD Wikipedia(Text) CC BY-SA