Species Human Entrez 84701 | Human Mouse Ensembl ENSG00000131055 | |
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Aliases COX4I2, COX4, COX4-2, COX4B, COX4L2, COXIV-2, dJ857M17.2, cytochrome c oxidase subunit 4I2 External IDs MGI: 2135755 HomoloGene: 13082 GeneCards: COX4I2 | ||
Cytochrome c oxidase subunit 4 isoform 2, mitochondrial is an enzyme that in humans is encoded by the COX4I2 gene.
Contents
Function
Cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved in the regulation and assembly of the complex. This nuclear gene encodes isoform 2 of subunit IV. Isoform 1 of subunit IV is encoded by a different gene, however, the two genes show a similar structural organization. Subunit IV is the largest nuclear encoded subunit which plays a pivotal role in COX regulation.
Interactions
COX4I2 has been shown to interact with Cytochrome c.