Entrez 10980 | Ensembl ENSG00000168090 | |
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Aliases COPS6, CSN6, MOV34-34KD, COP9 signalosome subunit 6 External IDs MGI: 1349439 HomoloGene: 4977 GeneCards: COPS6 | ||
COP9 signalosome complex subunit 6 is a protein that in humans is encoded by the COPS6 gene.
Contents
Function
The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein belongs to translation initiation factor 3 (eIF3) superfamily. It is involved in the regulation of cell cycle and likely to be a cellular cofactor for HIV-1 accessory gene product Vpr.
Interactions
COPS6 has been shown to interact with EIF3S6.