Entrez 25792 | Ensembl ENSG00000148337 | |
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External IDs MGI: 1920234 HomoloGene: 8112 GeneCards: CIZ1 | ||
Cip1-interacting zinc finger protein is a protein that in humans is encoded by the CIZ1 gene.
Contents
Function
The protein encoded by this gene is a zinc finger DNA binding transcription factor that interacts with CIP1 (p21 / CDKN1A), part of a complex with cyclin E. The encoded protein may regulate the cellular localization of CIP1.
Clinical significance
An altered circulating form of the Ciz1 protein is synthesized by lung cancer cells, even when they are at a very early stage. Hence detection of this protein variant in blood could be used as a biomarker for early detection of lung cancer.
Interactions
CIZ1 has been shown to interact with P21.
References
CIZ1 Wikipedia(Text) CC BY-SA