CHST11

Clinical relevance

Mutations in this gene have been associated to susceptibility for osteoarthritis.

Model organisms

Model organisms have been used in the study of CHST11 function. A conditional knockout mouse line called Chst11^{tm1a(KOMP)Wtsi} was generated at the Wellcome Trust Sanger Institute. Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion. Additional screens performed: - In-depth immunological phenotyping - in-depth bone and cartilage phenotyping