Trisha Shetty (Editor)

CENPF

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Species
  
Human

Entrez
  
1063

Human
  
Mouse

Ensembl
  
ENSG00000117724

Aliases
  
CENPF, CENF, PRO1779, hcp-1, CILD31, STROMS, centromere protein F

External IDs
  
MGI: 1313302 HomoloGene: 22969 GeneCards: CENPF

Centromere protein F is a protein that in humans is encoded by the CENPF gene.

This gene encodes a protein that associates with the centromere-kinetochore complex. The protein is a component of the nuclear matrix during the G2 phase of interphase. In late G2 the protein associates with the kinetochore and maintains this association through early anaphase. It localizes to the spindle midzone and the intracellular bridge in late anaphase and telophase, respectively, and is thought to be subsequently degraded. The localization of this protein suggests that it may play a role in chromosome segregation during mitotis. It is thought to form either a homodimer or heterodimer. Autoantibodies against this protein have been found in patients with cancer or graft versus host disease.

References

CENPF Wikipedia