Girish Mahajan (Editor)

CELA1

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Species
  
Human

Entrez
  
1990

Human
  
Mouse

Ensembl
  
ENSG00000139610

Aliases
  
CELA1, ELA1, chymotrypsin like elastase family member 1

External IDs
  
MGI: 95314 HomoloGene: 20454 GeneCards: CELA1

Chymotrypsin-like elastase family member 1 (CELA1) also known as elastase-1 (ELA1) is an enzyme that in humans is encoded by the CELA1 gene. Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B.

Contents

Tissue distribution

Elastase-1 was formerly designated pancreatic elastase 1. However unlike other elastases, pancreatic elastase 1 is not expressed in the pancreas. Hence this enzyme has been renamed as elastase-1. To date, elastase 1 expression has only been detected in skin keratinocytes. Literature that describes human elastase 1 activity in the pancreas or fecal material is actually referring to chymotrypsin-like elastase family, member 3B CELA3B).

Clinical significance

This enzyme has been linked to chronic pancreatitis .

References

CELA1 Wikipedia