Girish Mahajan (Editor)

CEBPD

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Species
  
Entrez
  
1052

Human
  
Ensembl
  
ENSG00000221869

Aliases
  
CEBPD, C/EBP-delta, CELF, CRP3, NF-IL6-beta, CCAAT/enhancer binding protein delta

External IDs
  
MGI: 103573 HomoloGene: 3808 GeneCards: CEBPD

CCAAT/enhancer-binding protein delta is a protein that in humans is encoded by the CEBPD gene.

Contents

Function

The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related protein CEBP-alpha. The encoded protein is important in the regulation of genes involved in immune and inflammatory responses, and may be involved in the regulation of genes associated with activation and/or differentiation of macrophages.

Functions

CEBPD is involved in regulation of apoptosis and cell proliferation. It probably acts as tumor suppressor.

One study in mice showed that CEBPD prevents development of tubular injury and tubulointerstitial fibrogenesis during the progression of chronic obstructive nephropathy.

Interactions

CEBPD has been shown to interact with Mothers against decapentaplegic homolog 3.

References

CEBPD Wikipedia


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