Species Human Entrez 10435 | Human Mouse Ensembl ENSG00000149798 | |
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Aliases CDC42EP2, BORG1, CEP2, CDC42 effector protein 2 External IDs MGI: 1929744 HomoloGene: 4933 GeneCards: CDC42EP2 | ||
Cdc42 effector protein 2 is a protein that in humans is encoded by the CDC42EP2 gene.
Contents
Function
CDC42, a small Rho GTPase, regulates the formation of F-actin-containing structures through its interaction with the downstream effector proteins. The protein encoded by this gene is a member of the Borg family of CDC42 effector proteins. Borg family proteins contain a CRIB (Cdc42/Rac interactive-binding) domain. They bind to, and negatively regulate the function of, CDC42. Coexpression of this protein with dominant negative mutant CDC42 protein in fibroblast was found to induce pseudopodia formation, which suggested a role of this protein in actin filament assembly and cell shape control.
Interactions
CDC42EP2 has been shown to interact with CDC42 and RHOQ.
References
CDC42EP2 Wikipedia(Text) CC BY-SA