Species Human Entrez 8476 | Human Mouse Ensembl ENSG00000143776 | |
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Aliases CDC42BPA, MRCK, MRCKA, PK428, CDC42 binding protein kinase alpha External IDs MGI: 2441841 HomoloGene: 55765 GeneCards: CDC42BPA | ||
Serine/threonine-protein kinase MRCK alpha is an enzyme that in humans is encoded by the CDC42BPA gene.
The protein encoded by this gene is a member of the Serine/Threonine protein kinase family. This kinase contains multiple functional domains. Its kinase domain is highly similar to that of the myotonic dystrophy protein kinase (DMPK). This kinase also contains a Rac interactive binding (CRIB) domain, and has been shown to bind CDC42. It may function as a CDC42 downstream effector mediating CDC42 induced peripheral actin formation, and promoting cytoskeletal reorganization. Multiple alternatively spliced transcript variants have been described, and the full-length nature of two of them has been reported.
References
CDC42BPA Wikipedia(Text) CC BY-SA