Entrez 8697 | Ensembl ENSG00000094880 | |
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Aliases CDC23, ANAPC8, APC8, CUT23, cell division cycle 23 External IDs MGI: 1098815 HomoloGene: 3426 GeneCards: CDC23 | ||
Cell division cycle 23 homolog (S. cerevisiae), also known as CDC23, is a protein that, in humans, is encoded by the CDC23 gene.
Contents
Function
The CDC23 protein shares strong similarity with Saccharomyces cerevisiae Cdc23, a protein essential for cell cycle progression through the G2/M transition. This protein is a component of anaphase-promoting complex (APC), which is composed of eight protein subunits and highly conserved in eukaryotic cells. APC catalyzes the formation of cyclin B-ubiquitin conjugate that is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. This protein and 3 other members of the APC complex contain the TPR (tetratricopeptide repeat), a protein domain important for protein-protein interaction.
Interactions
CDC23 has been shown to interact with CDC27.