Entrez 942 | Ensembl ENSG00000114013 | |
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Aliases CD86, B7-2, B7.2, B70, CD28LG2, LAB72, CD86 molecule External IDs OMIM: 601020 MGI: 101773 HomoloGene: 10443 GeneCards: CD86 |
Cluster of Differentiation 86 (also known as CD86 and B7-2) is a protein expressed on antigen-presenting cells that provides costimulatory signals necessary for T cell activation and survival. It is the ligand for two different proteins on the T cell surface: CD28 (for autoregulation and intercellular association) and CTLA-4 (for attenuation of regulation and cellular disassociation). CD86 works in tandem with CD80 to prime T cells.
The CD86 gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. Alternative splicing results in two transcript variants encoding different isoforms. Additional transcript variants have been described, but their full-length sequences have not been determined.
References
CD86 Wikipedia(Text) CC BY-SA