Kalpana Kalpana (Editor)

CD80

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Species
  
Entrez
  
941

Human
  
Ensembl
  
ENSG00000121594

CD80

Aliases
  
CD80, B7, B7-1, B7.1, BB1, CD28LG, CD28LG1, LAB7, CD80 molecule

External IDs
  
OMIM: 112203 MGI: 101775 HomoloGene: 3804 GeneCards: CD80

Cluster of differentiation 80 (also CD80 and B7-1) is a protein found on Dendritic cells, activated B cells and monocytes that provides a costimulatory signal necessary for T cell activation and survival. It is the ligand for two different proteins on the T cell surface: CD28 (for autoregulation and intercellular association) and CTLA-4 (for attenuation of regulation and cellular disassociation). CD80 works in tandem with CD86 to prime T cells.

References

CD80 Wikipedia


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