Species Human Entrez 941 | Human Mouse Ensembl ENSG00000121594 | |
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Aliases CD80, B7, B7-1, B7.1, BB1, CD28LG, CD28LG1, LAB7, CD80 molecule External IDs OMIM: 112203 MGI: 101775 HomoloGene: 3804 GeneCards: CD80 | ||
Cluster of differentiation 80 (also CD80 and B7-1) is a protein found on Dendritic cells, activated B cells and monocytes that provides a costimulatory signal necessary for T cell activation and survival. It is the ligand for two different proteins on the T cell surface: CD28 (for autoregulation and intercellular association) and CTLA-4 (for attenuation of regulation and cellular disassociation). CD80 works in tandem with CD86 to prime T cells.
References
CD80 Wikipedia(Text) CC BY-SA