Species Human Entrez 924 | Human Mouse Ensembl ENSG00000173762 | |
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Aliases CD7, GP40, LEU-9, TP41, Tp40, CD7 molecule External IDs MGI: 88344 HomoloGene: 4471 GeneCards: CD7 | ||
CD7 (Cluster of Differentiation 7) is a protein that in humans is encoded by the CD7 gene.
Contents
Function
This gene encodes a transmembrane protein which is a member of the immunoglobulin superfamily. This protein is found on thymocytes and mature T cells. It plays an essential role in T-cell interactions and also in T-cell/B-cell interaction during early lymphoid development.
Interactions
CD7 has been shown to interact with PIK3R1.
Clinical significance
CD7 can be aberrantly expressed in refractory anaemia with excess blasts (RAEB) and may confer a worse prognosis. Also, a lack of CD7 expression could insinuate mycosis fungoides (MF) or Sezary syndrome (SS).
References
CD7 Wikipedia(Text) CC BY-SA