Species Human Entrez 3690 | Human Mouse Ensembl ENSG00000259207 | |
 | ||
Aliases ITGB3, BDPLT16, BDPLT2, CD61, GP3A, GPIIIa, GT, integrin subunit beta 3 External IDs OMIM: 173470 MGI: 96612 HomoloGene: 55444 GeneCards: ITGB3 | ||
Integrin beta-3 (β3) or CD61 is a protein that in humans is encoded by the ITGB3 gene. CD61 is a cluster of differentiation found on thrombocytes.
Contents
Structure and function
The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface-mediated signaling.
Role in endometriosis
Defectively expressed β3 integrin subunit has been correlated with presence of endometriosis, and has been suggested as a putative marker of this condition.
Interactions
CD61 has been shown to interact with PTK2, ITGB3BP, TLN1 and CIB1.