Species Human Entrez 3689 | Human Mouse Ensembl ENSG00000160255 | |
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Aliases ITGB2, CD18, LAD, LCAMB, LFA-1, MAC-1, MF17, MFI7, integrin subunit beta 2 External IDs OMIM: 600065 MGI: 96611 HomoloGene: 20092 GeneCards: ITGB2 | ||
Integrin beta-2 (CD18) is a protein that in humans is encoded by the ITGB2 gene.
Contents
It is the beta subunit of four different structures:
Function
The ITGB2 protein product is the integrin beta chain beta 2. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, beta 2 combines with the alpha L chain to form the integrin LFA-1, and combines with the alpha M chain to form the integrin Mac-1. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling.
Clinical significance
In humans lack of CD18 causes Leukocyte Adhesion Deficiency, a disease defined by a lack of leukocyte extravasation from blood into tissues. The beta 2 integrins have also been found in a soluble form. The soluble beta 2 integrins are ligand binding and plasma levels are inversely associated with disease activity in the autoimmune disease spondyloarthritis.
Interactions
CD18 has been shown to interact with: