Species Human Entrez 977 | Human Mouse Ensembl ENSG00000177697 | |
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Aliases CD151, GP27, MER2, PETA-3, RAPH, SFA1, TSPAN24, CD151 molecule (Raph blood group) External IDs OMIM: 602243 MGI: 1096360 HomoloGene: 20916 GeneCards: CD151 | ||
CD151 molecule (Raph blood group), also known as CD151 (Cluster of Differentiation 151), is a human gene.
Contents
Function
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It is involved in cellular processes including cell adhesion and may regulate integrin trafficking and/or function. This protein enhances cell motility, invasion and metastasis of cancer cells. Multiple alternatively spliced transcript variants that encode the same protein have been described for this gene.
Interactions
CD151 has been shown to interact with CD46.